Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients.
BACKGROUND Vascular calcification has detrimental consequences on chronic kidney disease (CKD) patients, yet its pathogenesis is not fully understood. Fibroblast growth factor-23 (FGF-23) is involved in the regulation of mineral metabolism which may in turn affect vascular calcification. Data on the relationship between FGF-23 and peripheral vascular calcification, using conventional radiograph...
متن کاملParathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism.
The importance of fibroblast growth factor 23 (FGF-23) in the pathogenesis of phosphate wasting disorders has been established, but controversy remains about how parathyroid hormone (PTH), which also stimulates urinary phosphate excretion, regulates the circulating level of FGF-23. We found that the serum FGF-23 concentration was higher in PTH-cyclin D1 transgenic mice, a model of primary hyper...
متن کاملChanges in fibroblast growth factor 23 during treatment of secondary hyperparathyroidism with alfacalcidol or paricalcitol.
BACKGROUND Fibroblast growth factor 23 (FGF23) increases renal phosphate excretion and decreases the formation of 1,25 dihydroxyvitamin D. In patients with chronic kidney disease, plasma FGF23 levels are markedly elevated by unknown mechanisms. We explored the changes in FGF23 during treatment of secondary hyperparathyroidism (SHPT) with alfacalcidol or paricalcitol in haemodialysis patients. ...
متن کاملPrognostic Importance of Fibroblast Growth Factor-23 in Dialysis Patients
Introduction. In this study, we aimed to demonstrate the correlation of FGF-23 levels with bone-mineral metabolism, anemia, and the treatment in dialysis patients. Methods. Eighty-nine patients with similar age, gender, dialysis duration, and dialysis adequacy who were receiving hemodialysis replacement therapy for at least 6 months were included in the study. Serum iron, iron binding capacity,...
متن کاملHigh levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients.
BACKGROUND Fibroblast growth factor (FGF)-23, a novel bone-derived phosphaturic factor involved in mineral metabolism, is increased in chronic kidney disease (CKD); in dialysis patients, it has been linked to increased mortality rates and vascular calcification (VC). The present investigation aimed to study the factors associated with elevated serum FGF-23 levels in patients treated with long h...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2004
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1510055